Which disinfectant should be used on surfaces contaminated with C. difficile?

Using bleach, specifically sodium hypochlorite at a concentration of 5.25%, is the recommended disinfectant for surfaces contaminated with C. difficile. This is due to the unique properties of C. difficile spores, which are particularly resistant to many common disinfectants.

Bleach is effective against these spores because it is a strong oxidizing agent that can destroy the cellular structure and proteins of the bacteria, thereby killing the pathogen and preventing further spread. Infection control guidelines emphasize the use of bleach for cleaning surfaces where C. difficile has been present, as it significantly reduces the risk of transmission within healthcare settings.

Other disinfectants, such as 70% ethyl alcohol, iodophors, and phenolic disinfectants, do not provide the same level of efficacy against C. difficile spores. While these may be effective against other pathogens, they do not meet the specific requirements for C. difficile, which is why bleach remains the standard recommendation in such cases.